MovDisordV3, Main, Exploration, bibRecord, 004552

Brainstem motor loops in the control of movement

Identifieur interne : 004552 ( Main/Exploration ); précédent : 004551; suivant : 004553

Brainstem motor loops in the control of movement

Auteurs : Dipankar Nandi [Royaume-Uni] ; Tipu Z. Aziz [Royaume-Uni] ; Xuguang Liu [Royaume-Uni] ; John F. Stein [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2002-03.

RBID : ISTEX:9FFAC86887229259FD2C48217177EEAFB5DD3A9D

Descripteurs français

Pascal (Inist)
- Akinésie, Animal, Article synthèse, Homme, Modèle animal, Physiopathologie, Tronc cérébral.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Akinesia, Animal, Animal model, Animals, Bicuculline (pharmacology), Brain Stem (anatomy & histology), Brain Stem (physiology), Brain Stem (physiopathology), Brain stem, Electric Stimulation, GABA Agonists (pharmacology), GABA Antagonists (pharmacology), Human, Humans, MPTP Poisoning (physiopathology), Macaca mulatta, Motor Activity (physiology), Movement (physiology), Muscimol (pharmacology), Neural Pathways (anatomy & histology), Neural Pathways (physiology), Pathophysiology, Review, Subthalamus (anatomy & histology), Subthalamus (physiology), Subthalamus (physiopathology), Tegmentum Mesencephali (anatomy & histology), Tegmentum Mesencephali (physiology), Tegmentum Mesencephali (physiopathology), Tremor (physiopathology), Tremor (therapy), akinesia, pedunculopontine nucleus, proximal tremor, zona incerta.
MESH :
- chemical , pharmacology : Bicuculline, GABA Agonists, GABA Antagonists, Muscimol.
- anatomy & histology : Brain Stem, Neural Pathways, Subthalamus, Tegmentum Mesencephali.
- physiology : Brain Stem, Motor Activity, Movement, Neural Pathways, Subthalamus, Tegmentum Mesencephali.
- physiopathology : Brain Stem, MPTP Poisoning, Subthalamus, Tegmentum Mesencephali, Tremor.
- therapy : Tremor.
- Animals, Electric Stimulation, Humans, Macaca mulatta.

Abstract

In recent years, the role of the area around the upper brainstem, particularly the pedunculopontine (PPN) region and the zona incerta (ZI), in the initiation and control of movement has generated much clinical interest. Using electrophysiological and pharmacological methods, we have further explored these structures and their influence in motor control in the nonhuman primate and in patients with proximal tremor. We have found that lesioning the PPN and electrical stimulation at high frequencies of the PPN region in the normal‐behaving primate induces akinesia, and low frequency stimulation can induce tremor. In the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine hydrochloride (MPTP) ‐treated parkinsonian primate model, bicuculline, a γ‐aminobutyric acid antagonist, can alleviate akinesia when infused into the PPN region. Further studies will elucidate the possible clinical implications of these observations. The ZI has reciprocal connections with several cortical areas, the upper brainstem, cerebellum, and thalamus. We have found that chronic, high‐frequency deep brain stimulation of the ZI suppresses proximal limb tremor. Field potential recordings from the ZI show significant coherence with concurrent proximal muscle electromyograms. This finding has potential clinical relevance as proximal tremor generally does not respond well to thalamic surgery and may be severely disabling. © 2002 Movement Disorder Society

Url:

https://api.istex.fr/document/9FFAC86887229259FD2C48217177EEAFB5DD3A9D/fulltext/pdf

DOI: 10.1002/mds.10139

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brainstem motor loops in the control of movement</title>
<author><name sortKey="Nandi, Dipankar" sort="Nandi, Dipankar" uniqKey="Nandi D" first="Dipankar" last="Nandi">Dipankar Nandi</name>
</author>
<author><name sortKey="Aziz, Tipu Z" sort="Aziz, Tipu Z" uniqKey="Aziz T" first="Tipu Z." last="Aziz">Tipu Z. Aziz</name>
</author>
<author><name sortKey="Liu, Xuguang" sort="Liu, Xuguang" uniqKey="Liu X" first="Xuguang" last="Liu">Xuguang Liu</name>
</author>
<author><name sortKey="Stein, John F" sort="Stein, John F" uniqKey="Stein J" first="John F." last="Stein">John F. Stein</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9FFAC86887229259FD2C48217177EEAFB5DD3A9D</idno>
<date when="2002" year="2002">2002</date>
<idno type="doi">10.1002/mds.10139</idno>
<idno type="url">https://api.istex.fr/document/9FFAC86887229259FD2C48217177EEAFB5DD3A9D/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001147</idno>
<idno type="wicri:Area/Istex/Curation">001147</idno>
<idno type="wicri:Area/Istex/Checkpoint">002E44</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Nandi D:brainstem:motor:loops</idno>
<idno type="wicri:Area/Main/Merge">006558</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:02-0309267</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002812</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000509</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002840</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Nandi D:brainstem:motor:loops</idno>
<idno type="wicri:Area/Main/Merge">006879</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:11948752</idno>
<idno type="wicri:Area/PubMed/Corpus">003A97</idno>
<idno type="wicri:Area/PubMed/Curation">003A97</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003B75</idno>
<idno type="wicri:Area/Ncbi/Merge">000754</idno>
<idno type="wicri:Area/Ncbi/Curation">000754</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000754</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Nandi D:brainstem:motor:loops</idno>
<idno type="wicri:Area/Main/Merge">006224</idno>
<idno type="wicri:Area/Main/Curation">004552</idno>
<idno type="wicri:Area/Main/Exploration">004552</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brainstem motor loops in the control of movement</title>
<author><name sortKey="Nandi, Dipankar" sort="Nandi, Dipankar" uniqKey="Nandi D" first="Dipankar" last="Nandi">Dipankar Nandi</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University Laboratory of Physiology, Oxford University, Parks Road, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aziz, Tipu Z" sort="Aziz, Tipu Z" uniqKey="Aziz T" first="Tipu Z." last="Aziz">Tipu Z. Aziz</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University Laboratory of Physiology, Oxford University, Parks Road, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurosurgery, Radcliffe Infirmary, Woodstock Road, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Xuguang" sort="Liu, Xuguang" uniqKey="Liu X" first="Xuguang" last="Liu">Xuguang Liu</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University Laboratory of Physiology, Oxford University, Parks Road, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, John F" sort="Stein, John F" uniqKey="Stein J" first="John F." last="Stein">John F. Stein</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University Laboratory of Physiology, Oxford University, Parks Road, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2002-03">2002-03</date>
<biblScope unit="vol">17</biblScope>
<biblScope unit="issue">S3</biblScope>
<biblScope unit="supplement">3</biblScope>
<biblScope unit="page" from="S22">S22</biblScope>
<biblScope unit="page" to="S27">S27</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">9FFAC86887229259FD2C48217177EEAFB5DD3A9D</idno>
<idno type="DOI">10.1002/mds.10139</idno>
<idno type="ArticleID">MDS10139</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Akinesia</term>
<term>Animal</term>
<term>Animal model</term>
<term>Animals</term>
<term>Bicuculline (pharmacology)</term>
<term>Brain Stem (anatomy & histology)</term>
<term>Brain Stem (physiology)</term>
<term>Brain Stem (physiopathology)</term>
<term>Brain stem</term>
<term>Electric Stimulation</term>
<term>GABA Agonists (pharmacology)</term>
<term>GABA Antagonists (pharmacology)</term>
<term>Human</term>
<term>Humans</term>
<term>MPTP Poisoning (physiopathology)</term>
<term>Macaca mulatta</term>
<term>Motor Activity (physiology)</term>
<term>Movement (physiology)</term>
<term>Muscimol (pharmacology)</term>
<term>Neural Pathways (anatomy & histology)</term>
<term>Neural Pathways (physiology)</term>
<term>Pathophysiology</term>
<term>Review</term>
<term>Subthalamus (anatomy & histology)</term>
<term>Subthalamus (physiology)</term>
<term>Subthalamus (physiopathology)</term>
<term>Tegmentum Mesencephali (anatomy & histology)</term>
<term>Tegmentum Mesencephali (physiology)</term>
<term>Tegmentum Mesencephali (physiopathology)</term>
<term>Tremor (physiopathology)</term>
<term>Tremor (therapy)</term>
<term>akinesia</term>
<term>pedunculopontine nucleus</term>
<term>proximal tremor</term>
<term>zona incerta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Bicuculline</term>
<term>GABA Agonists</term>
<term>GABA Antagonists</term>
<term>Muscimol</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Brain Stem</term>
<term>Neural Pathways</term>
<term>Subthalamus</term>
<term>Tegmentum Mesencephali</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain Stem</term>
<term>Motor Activity</term>
<term>Movement</term>
<term>Neural Pathways</term>
<term>Subthalamus</term>
<term>Tegmentum Mesencephali</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Stem</term>
<term>MPTP Poisoning</term>
<term>Subthalamus</term>
<term>Tegmentum Mesencephali</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Electric Stimulation</term>
<term>Humans</term>
<term>Macaca mulatta</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Akinésie</term>
<term>Animal</term>
<term>Article synthèse</term>
<term>Homme</term>
<term>Modèle animal</term>
<term>Physiopathologie</term>
<term>Tronc cérébral</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In recent years, the role of the area around the upper brainstem, particularly the pedunculopontine (PPN) region and the zona incerta (ZI), in the initiation and control of movement has generated much clinical interest. Using electrophysiological and pharmacological methods, we have further explored these structures and their influence in motor control in the nonhuman primate and in patients with proximal tremor. We have found that lesioning the PPN and electrical stimulation at high frequencies of the PPN region in the normal‐behaving primate induces akinesia, and low frequency stimulation can induce tremor. In the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine hydrochloride (MPTP) ‐treated parkinsonian primate model, bicuculline, a γ‐aminobutyric acid antagonist, can alleviate akinesia when infused into the PPN region. Further studies will elucidate the possible clinical implications of these observations. The ZI has reciprocal connections with several cortical areas, the upper brainstem, cerebellum, and thalamus. We have found that chronic, high‐frequency deep brain stimulation of the ZI suppresses proximal limb tremor. Field potential recordings from the ZI show significant coherence with concurrent proximal muscle electromyograms. This finding has potential clinical relevance as proximal tremor generally does not respond well to thalamic surgery and may be severely disabling. © 2002 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Oxfordshire</li>
</region>
<settlement><li>Oxford</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Nandi, Dipankar" sort="Nandi, Dipankar" uniqKey="Nandi D" first="Dipankar" last="Nandi">Dipankar Nandi</name>
</region>
<name sortKey="Aziz, Tipu Z" sort="Aziz, Tipu Z" uniqKey="Aziz T" first="Tipu Z." last="Aziz">Tipu Z. Aziz</name>
<name sortKey="Aziz, Tipu Z" sort="Aziz, Tipu Z" uniqKey="Aziz T" first="Tipu Z." last="Aziz">Tipu Z. Aziz</name>
<name sortKey="Liu, Xuguang" sort="Liu, Xuguang" uniqKey="Liu X" first="Xuguang" last="Liu">Xuguang Liu</name>
<name sortKey="Stein, John F" sort="Stein, John F" uniqKey="Stein J" first="John F." last="Stein">John F. Stein</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004552 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004552 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:9FFAC86887229259FD2C48217177EEAFB5DD3A9D
   |texte=   Brainstem motor loops in the control of movement
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Brainstem motor loops in the control of movement

Brainstem motor loops in the control of movement

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.